{"id":324,"date":"2020-11-17T17:39:54","date_gmt":"2020-11-17T10:39:54","guid":{"rendered":"http:\/\/phongkham.lamgia.asia\/?p=324"},"modified":"2020-11-17T17:39:54","modified_gmt":"2020-11-17T10:39:54","slug":"nghien-cuu-kham-pha-te-bao-gianh-giai-nobel-y-sinh-2019","status":"publish","type":"post","link":"https:\/\/nhikhoathanhhong.com\/wnkth\/?p=324","title":{"rendered":"Nghi\u00ean c\u1ee9u kh\u00e1m ph\u00e1 t\u1ebf b\u00e0o gi\u00e0nh gi\u1ea3i Nobel Y sinh 2019"},"content":{"rendered":"

Vi\u1ec7n h\u00e0n l\u00e2m Khoa h\u1ecdc Ho\u00e0ng gia Th\u1ee5y \u0110i\u1ec3n (RSAS) trao gi\u1ea3i Nobel 2019 cho ba nh\u00e0 khoa h\u1ecdc trong \u0111\u00f3 c\u00f3 hai ng\u01b0\u1eddi M\u1ef9 v\u00e0 m\u1ed9t ng\u01b0\u1eddi Anh, l\u00e0 c\u00e1c t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1ch t\u1ebf b\u00e0o c\u1ea3m nh\u1eadn v\u00e0 th\u00edch \u1ee9ng v\u1edbi m\u1ee9c \u0111\u1ed9 oxy s\u1eb5n c\u00f3. Kh\u00e1m ph\u00e1 n\u00e0y c\u00f3 th\u1ec3 m\u1edf ra nh\u1eefng c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh suy tim, thi\u1ebfu m\u00e1u v\u00e0 ung th\u01b0.<\/strong><\/p>\n

Nobel Y sinh l\u00e0 gi\u1ea3i \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 \u0111\u1ea7u ti\u00ean trong chu\u1ed7i c\u00e1c gi\u1ea3i Nobel danh gi\u00e1. Gi\u1ea3i Nobel \u0111\u01b0\u1ee3c trao cho c\u00e1c th\u00e0nh t\u1ef1u trong khoa h\u1ecdc, v\u0103n ch\u01b0\u01a1ng v\u00e0 h\u00f2a b\u00ecnh. \u0110\u00e2y l\u00e0 gi\u1ea3i th\u01b0\u1edfng \u0111\u01b0\u1ee3c ra \u0111\u1eddi t\u1eeb n\u0103m 1901 theo di nguy\u1ec7n c\u1ee7a nh\u00e0 s\u00e1ng ch\u1ebf v\u00e0 doanh nh\u00e2n Alfred Nobel. \u0110i k\u00e8m gi\u1ea3i Nobel l\u00e0 9 tri\u1ec7u crown Th\u1ee5y \u0110i\u1ec3n, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 913.000 USD s\u1ebd \u0111\u01b0\u1ee3c chia \u0111\u1ec1u cho c\u1ea3 ba ng\u01b0\u1eddi.<\/p>\n

Gi\u1ea3i th\u01b0\u1edfng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 t\u1ea1i Th\u1ee5y \u0110i\u1ec3n. Theo \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u01b0\u1ee3c trao gi\u1ea3i Nobel Y sinh 2019 g\u1ed3m William Kaelin v\u00e0 Gregg Semenza ng\u01b0\u1eddi M\u1ef9; Peter Ratcliffe, ng\u01b0\u1eddi Anh. H\u1ed9i \u0111\u1ed3ng Nobel Th\u1ee5y \u0110i\u1ec3n cho bi\u1ebft: “Ph\u00e1t hi\u1ec7n c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc gi\u00e0nh gi\u1ea3i Nobel n\u0103m nay cho th\u1ea5y r\u00f5 c\u01a1 ch\u1ebf c\u1ee7a m\u1ed9t trong c\u00e1c qu\u00e1 tr\u00ecnh th\u00edch \u1ee9ng quan tr\u1ecdng nh\u1ea5t c\u1ee7a s\u1ef1 s\u1ed1ng\u201d.<\/p>\n

\"\"C\u00f4ng b\u1ed1 3 nh\u00e0 khoa h\u1ecdc \u0111o\u1ea1t gi\u1ea3i Nobel Y sinh n\u0103m 2019<\/em><\/p>\n

Nghi\u00ean c\u1ee9u c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc tr\u00ean \u0111\u1eb7t n\u1ec1n m\u00f3ng \u0111\u1ec3 ch\u00fang ta th\u1ea5u hi\u1ec3u m\u1ee9c \u0111\u1ed9 oxy \u1ea3nh h\u01b0\u1edfng nh\u01b0 th\u1ebf n\u00e0o \u0111\u1ebfn c\u00e1c ch\u1ee9c n\u0103ng chuy\u1ec3n h\u00f3a v\u00e0 sinh l\u00fd c\u1ee7a t\u1ebf b\u00e0o. “C\u1ea3m bi\u1ebfn oxy l\u00e0 v\u1ea5n \u0111\u1ec1 c\u1ed1t l\u00f5i trong nghi\u00ean c\u1ee9u r\u1ea5t nhi\u1ec1u lo\u1ea1i b\u1ec7nh”, H\u1ed9i \u0111\u1ed3ng Nobel \u0111\u00e1nh gi\u00e1. “Nh\u1eefng n\u1ed7 l\u1ef1c kh\u00f4ng m\u1ec7t m\u1ecfi c\u1ee7a c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 c\u00e1c c\u00f4ng ty d\u01b0\u1ee3c hi\u1ec7n nay \u0111ang t\u1eadp trung nh\u1eb1m ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 can thi\u1ec7p v\u00e0o b\u1ec7nh t\u00ecnh, b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t ho\u1eb7c ng\u0103n ch\u1eb7n c\u01a1 ch\u1ebf c\u1ea3m bi\u1ebfn oxy”.<\/p>\n

C\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u c\u1ee7a ba nh\u00e0 khoa h\u1ecdc thi\u1ebft l\u1eadp s\u1ef1 hi\u1ec3u bi\u1ebft v\u1ec1 m\u1ee9c \u0111\u1ed9 oxy \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o v\u00e0 ch\u1ee9c n\u0103ng sinh l\u00fd, m\u1edf ra nh\u1eefng c\u1ea3nh c\u1eeda m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n trong \u0111i\u1ec1u tr\u1ecb thi\u1ebfu m\u00e1u, ung th\u01b0, v\u00e0 nhi\u1ec1u b\u1ec7nh kh\u00e1c.<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u01b0\u1ee3c trao gi\u1ea3i Nobel Y sinh 2019 g\u1ed3m William Kaelin v\u00e0 Gregg Semenza ng\u01b0\u1eddi M\u1ef9; Peter Ratcliffe, ng\u01b0\u1eddi Anh. Trong \u0111\u00f3, \u00f4ng William Kaelin l\u00e0 Gi\u00e1o s\u01b0 y khoa t\u1ea1i \u0110\u1ea1i h\u1ecdc Harvard, t\u1eebng \u0111\u01b0\u1ee3c trao gi\u1ea3i th\u01b0\u1edfng Lasker cho nghi\u00ean c\u1ee9u y h\u1ecdc c\u01a1 b\u1ea3n n\u0103m 2016 v\u00e0 Gi\u1ea3i th\u01b0\u1edfng Khoa h\u1ecdc Ung th\u01b0 ASCO 2016. Ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng nghi\u00ean c\u1ee9u c\u00e1c protein \u1ee9c ch\u1ebf kh\u1ed1i u. \u00d4ng cho bi\u1ebft, khi nh\u1eadn \u0111\u01b0\u1ee3c cu\u1ed9c g\u1ecdi v\u00e0o l\u00fac 5 gi\u1edd s\u00e1ng, \u00f4ng c\u1ea3m th\u1ea5y cho\u00e1ng v\u00e1ng v\u00e0 c\u1ee9 ngh\u0129 \u0111\u00e2y l\u00e0 gi\u1ea5c m\u01a1.<\/p>\n

Nh\u00e0 khoa h\u1ecdc Gregg Semenza l\u00e0 Gi\u00e1o s\u01b0 khoa ung th\u01b0, h\u00f3a h\u1ecdc sinh h\u1ecdc v\u00e0 y h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Y khoa Johns Hopkins. \u00d4ng l\u00e0 gi\u00e1m \u0111\u1ed1c ch\u01b0\u01a1ng tr\u00ecnh m\u1ea1ch m\u00e1u t\u1ea1i Vi\u1ec7n K\u1ef9 thu\u1eadt t\u1ebf b\u00e0o. \u00d4ng l\u00e0 ng\u01b0\u1eddi nh\u1eadn gi\u1ea3i th\u01b0\u1edfng Lasker n\u0103m 2016 cho nghi\u00ean c\u1ee9u y h\u1ecdc c\u01a1 b\u1ea3n.<\/p>\n

Ng\u01b0\u1eddi th\u1ee9 ba c\u00f9ng nh\u1eadn gi\u1ea3i Nobel Y h\u1ecdc n\u0103m nay l\u00e0 \u00f4ng Peter Ratcliffe l\u00e0 m\u1ed9t b\u00e1c s\u0129 ng\u01b0\u1eddi Anh, \u0111\u1ed3ng th\u1eddi l\u00e0 nh\u00e0 sinh h\u1ecdc t\u1ebf b\u00e0o v\u00e0 ph\u00e2n t\u1eed n\u1ed5i ti\u1ebfng v\u1edbi c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng c\u1ee7a t\u1ebf b\u00e0o \u0111\u1ed1i v\u1edbi t\u00ecnh tr\u1ea1ng thi\u1ebfu \u00f4xy. \u00d4ng c\u00f2n l\u00e0 th\u00e0nh vi\u00ean H\u1ecdc vi\u1ec7n Francis Crick \u1edf London (Anh).<\/p>\n

H\u01b0\u1edbng nghi\u00ean c\u1ee9u m\u1edbi trong \u0111i\u1ec1u tr\u1ecb suy tim, thi\u1ebfu m\u00e1u v\u00e0 ung th\u01b0<\/strong>
\nC\u00e1c chuy\u00ean gia c\u1ee7a \u1ee6y ban Nobel cho bi\u1ebft, d\u00f9 ng\u01b0\u1eddi ta bi\u1ebft r\u1eb1ng \u00f4xy l\u00e0 thi\u1ebft y\u1ebfu \u0111\u1ec3 duy tr\u00ec s\u1ef1 s\u1ed1ng, tuy nhi\u00ean c\u01a1 ch\u1ebf ph\u00e2n t\u1eed \u0111\u1eb1ng sau c\u00e1ch c\u00e1c t\u1ebf b\u00e0o ph\u1ea3n \u1ee9ng khi l\u01b0\u1ee3ng cung \u00f4xy gi\u1ea3m ho\u1eb7c t\u0103ng v\u1eabn l\u00e0 b\u00ed \u1ea9n. V\u00e0 c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u1ea1t gi\u1ea3i n\u0103m nay ch\u00ednh l\u00e0 ng\u01b0\u1eddi gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c c\u01a1 ch\u1ebf \u0111\u00f3.<\/p>\n

C\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u c\u1ee7a ba nh\u00e0 khoa h\u1ecdc gi\u1ea3i th\u00edch c\u01a1 ch\u1ebf t\u1ebf b\u00e0o quy \u0111\u1ecbnh ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c gene ph\u1ea3n \u1ee9ng l\u1ea1i c\u00e1c m\u1ee9c \u0111\u1ed9 oxy kh\u00e1c nhau, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o v\u00e0 ch\u1ee9c n\u0103ng sinh l\u00fd, m\u1edf ra nh\u1eefng c\u1ea3nh c\u1eeda m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n trong \u0111i\u1ec1u tr\u1ecb thi\u1ebfu m\u00e1u, ung th\u01b0, v\u00e0 nhi\u1ec1u b\u1ec7nh kh\u00e1c. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u01a1 ch\u1ebf c\u1ea3m nh\u1eadn \u00f4xy xu\u1ea5t hi\u1ec7n trong g\u1ea7n nh\u01b0 m\u1ecdi t\u1ebf b\u00e0o. Khi m\u1ee9c \u00f4xy trong m\u00e1u th\u1ea5p, c\u00f2n g\u1ecdi l\u00e0 hypoxia, m\u1ed9t lo\u1ea1i ph\u1ee9c h\u1ee3p protein g\u1ecdi l\u00e0 t\u00e1c nh\u00e2n c\u1ea3m \u1ee9ng hypoxia (HIF) s\u1ebd t\u0103ng l\u00ean, \u0111\u1ec3 g\u1eafn v\u00e0o ADN c\u00f3 th\u1ec3 k\u1ebft n\u1ed1i v\u00e0 \u0111i\u1ec1u ch\u1ec9nh gene EPO (xu\u1ea5t hi\u1ec7n khi m\u1ee9c \u00f4xy th\u1ea5p trong m\u00e1u) c\u0169ng nh\u01b0 c\u00e1c gene kh\u00e1c c\u00f3 ph\u1ea7n ADN g\u1eafn k\u1ebft v\u1edbi HIF.<\/p>\n

C\u00e1c nghi\u00ean c\u1ee9u c\u1ee7a h\u1ecd cho th\u1ea5y khi m\u1ee9c oxy cao, t\u1ebf b\u00e0o ch\u1ee9a r\u1ea5t \u00edt HIF. Nh\u01b0ng khi m\u1ee9c oxy th\u1ea5p, l\u01b0\u1ee3ng HIF t\u0103ng l\u00ean \u0111\u1ec3 g\u1eafn v\u00e0o ADN c\u00f3 th\u1ec3 k\u1ebft n\u1ed1i v\u00e0 \u0111i\u1ec1u ch\u1ec9nh gene EPO c\u0169ng nh\u01b0 c\u00e1c gene kh\u00e1c c\u00f3 ph\u1ea7n ADN g\u1eafn k\u1ebft v\u1edbi HIF.<\/p>\n

Gi\u00e1o s\u01b0 t\u1ea1i Vi\u1ec7n Karolinska c\u1ee7a Th\u1ee5y \u0110i\u1ec3n Randall Johnson l\u1ea5y v\u00ed d\u1ee5, trong qu\u00e1 tr\u00ecnh t\u1eadp luy\u1ec7n, c\u01a1 th\u1ec3 trao \u0111\u1ed5i \u00f4xy v\u1edbi t\u1ed1c \u0111\u1ed9 cao, t\u1ebf b\u00e0o ph\u1ea3i \u201cb\u1eadt c\u00f4ng t\u1eafc\u201d t\u00ecm ra l\u01b0\u1ee3ng \u00f4xy c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111\u00e1p \u1ee9ng. \u1ede ng\u01b0\u1eddi b\u1ec7nh \u0111\u1ed9t qu\u1ef5, khi \u00f4xy kh\u00f4ng t\u1edbi n\u00e3o, nh\u1eefng t\u1ebf b\u00e0o \u1edf n\u00e3o n\u1ebfu s\u1ed1ng s\u00f3t, c\u1ea7n ph\u1ea3i th\u00edch nghi v\u1edbi m\u1ee9c \u00f4xy th\u1ea5p th\u1ebf n\u00e0o. Nh\u00e0 nghi\u00ean c\u1ee9u ung th\u01b0 \u0110\u1ea1i h\u1ecdc Oxford , Amato Giaccia cho bi\u1ebft, nhi\u1ec1u lo\u1ea1i gen \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t trong m\u00f4i tr\u01b0\u1eddng thi\u1ebfu \u00f4xy v\u00e0 ngay trong c\u00e1c t\u1ebf b\u00e0o \u1edf kh\u1ed1i u. Nghi\u00ean c\u1ee9u n\u00e0y s\u1ebd m\u1edf ra nhi\u1ec1u h\u01b0\u1edbng \u0111i m\u1edbi trong l\u0129nh v\u1ef1c y khoa.<\/p>\n

N\u0103m 2018, gi\u1ea3i Y sinh thu\u1ed9c v\u1ec1 hai nh\u00e0 khoa h\u1ecdc M\u1ef9 v\u00e0 Nh\u1eadt v\u1edbi nghi\u00ean c\u1ee9u v\u1ec1 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0.<\/p>\n","protected":false},"excerpt":{"rendered":"

Vi\u1ec7n h\u00e0n l\u00e2m Khoa h\u1ecdc Ho\u00e0ng gia Th\u1ee5y \u0110i\u1ec3n (RSAS) trao gi\u1ea3i Nobel 2019 cho ba nh\u00e0 khoa h\u1ecdc trong \u0111\u00f3 c\u00f3 hai ng\u01b0\u1eddi M\u1ef9 v\u00e0 m\u1ed9t ng\u01b0\u1eddi Anh, l\u00e0 c\u00e1c t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1ch t\u1ebf b\u00e0o c\u1ea3m nh\u1eadn v\u00e0 th\u00edch \u1ee9ng v\u1edbi m\u1ee9c \u0111\u1ed9 oxy s\u1eb5n c\u00f3. Kh\u00e1m ph\u00e1 n\u00e0y c\u00f3 th\u1ec3…<\/p>\n","protected":false},"author":1,"featured_media":325,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2,12,8,7,16],"tags":[],"yoast_head":"\nNghi\u00ean c\u1ee9u kh\u00e1m ph\u00e1 t\u1ebf b\u00e0o gi\u00e0nh gi\u1ea3i Nobel Y sinh 2019 - Nhi khoa Thanh H\u1ed3ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nhikhoathanhhong.com\/wnkth\/?p=324\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nghi\u00ean c\u1ee9u kh\u00e1m ph\u00e1 t\u1ebf b\u00e0o gi\u00e0nh gi\u1ea3i Nobel Y sinh 2019 - Nhi khoa Thanh H\u1ed3ng\" \/>\n<meta property=\"og:description\" content=\"Vi\u1ec7n h\u00e0n l\u00e2m Khoa h\u1ecdc Ho\u00e0ng gia Th\u1ee5y \u0110i\u1ec3n (RSAS) trao gi\u1ea3i Nobel 2019 cho ba nh\u00e0 khoa h\u1ecdc trong \u0111\u00f3 c\u00f3 hai ng\u01b0\u1eddi M\u1ef9 v\u00e0 m\u1ed9t ng\u01b0\u1eddi Anh, l\u00e0 c\u00e1c t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1ch t\u1ebf b\u00e0o c\u1ea3m nh\u1eadn v\u00e0 th\u00edch \u1ee9ng v\u1edbi m\u1ee9c \u0111\u1ed9 oxy s\u1eb5n c\u00f3. 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